IT’S TIME YOU KNOW ABOUT TYK2
Pathbreaking research is shedding light on the role of TYK2 in immunology
Certain immune-mediated diseases are characterized by the elevation of inflammatory cytokines regulated by several components. The tyrosine kinase 2 pathway plays a critical role in regulating certain triggers of inflammation involved in immune diseases.1,2
Tyrosine kinase 2 (TYK2) is an intracellular enzyme involved in the relay of immune signals initiated by specific cytokines, including IL-23, IL-12 and Type I IFN.1,2
TYK2 is a central link between certain cytokines, such as IL-23, IL-12 and Type I IFN, and the downstream effects of these cytokines.3
Select each tile.
IL-23 signaling through TYK2/JAK2 is critical in the expansion and survival of pathogenic Th17 cells as well as the induction of innate lymphoid cells in autoimmunity.4-6
IL-12-induced TYK2/JAK2 activation initiates recruitment and phosphorylation of STAT4, which activates transcription of a major effector molecule in systemic immune disorders.4,5
Activation by type I IFNs signaling through TYK2/JAK1 in the B cell impacts pathways important in autoimmunity such as B-cell differentiation, antibody production, and immunoglobulin isotype class switching.7
See the TYK2 pathway in action
LEARN ABOUT THE PATHWAYS
Understand the differences
TYK2 and JAK1/2/3 are structurally different from each other8
The regulatory, or pseudokinase, domain of TYK2 and JAK1/2/3 are different from each other.8
Active (ATP-binding) domain: similar across family members8
TYK2 and JAK1/2/3 are functionally different from each other9,10
TYK2 and JAK1/2/3 proteins form different dimers to mediate different sets of cytokine signals that can influence immune and/or systemic responses.9,10
The TYK2 and JAK1/2 pairs specifically mediate signals involved in immune functions2,3,10
JAK/JAK pairs mediate signals predominantly involved in both immune and broad systemic functions (eg, blood cell development, lipid metabolism)9-13
*Please note that this list of cytokines and effects modulated by the different TYK2/JAK and JAK/JAK pairs is not exhaustive. Certain cytokines might also be modulated by JAK and TYK2 trimers.2
ATP=adenosine triphosphate; EPO=erythropoietin; GH=growth hormone; GM-CSF=granulocyte-macrophage colony-stimulating factor; IFN=interferon; IL=interleukin; JAK=Janus kinase; TPO=thrombopoietin; TYK2=tyrosine kinase 2.
EXPLORING TYK2 RESEARCH
At BMS, we are committed to helping patients prevail over serious immune-related diseases such as psoriasis. We’re excited about our innovative research on the TYK2 pathway and the role it may play in immunology.
Download the TYK2 Fact Sheet